Establishment of new preparation method for solid dispersion formulation of tacrolimus

Kazunari Yamashita, Toshiomi Nakate, Kazuto Okimoto, +5

International Journal of Pharmaceutics

Biomedical EngineeringNew Preparation MethodPharmaceutical TechnologySolid Dispersion Formulation

Tacrolimus is a class II low-solubility high-permeability drug: The effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats

Shigeki Tamura, Atsuo Ohike, Rinta Ibuki, +2

Journal of Pharmaceutical Sciences

Molecular PharmacologyBiochemistryMedicinePhysiologyP-glycoprotein Efflux +3

Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine

Nobuyuki Tanaka, Keiji Imai, Kazuto Okimoto, +6

Journal of Controlled Release

Pharmaceutical ScienceNovel Sustained-release SystemDisintegration-controlled Matrix TabletSolid Dispersion GranulesPharmaceutical Technology +5

Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE)7m-β-CD as both a solubilizer and osmotic agent

Kazuto Okimoto, Atsuo Ohike, Rinta Ibuki, +6

Journal of Controlled Release

Osmotic AgentPharmaceutical ScienceMedicinePharmaceutical TechnologyOsmotic Pump Tablet +6

Design and Evaluation of an Osmotic Pump Tablet (OPT) for Chlorpromazine Using (SBE)7m-β-CD

Kazuto Okimoto, Atsuo Ohike, Rinta Ibuki, +6

Pharmaceutical Research

Flying characteristics and flow pattern of a sphere with dimples

Kazuhiro Aoki, Atsuo Ohike, Kenichiro Yamaguchi, +1

Journal of Visualization

Unsteady FlowAeronauticsEngineeringGeometryAerospace Engineering +6

Granulation Monitoring by Fast Fourier Transform Technique.

Atsuo Ohike, Kenichi Ashihara, Rinta Ibuki

Chemical and Pharmaceutical Bulletin

Geotechnical EngineeringMonitoring TechnologyReal-time MonitoringWet Granulation ProcessEnvironmental Monitoring +13

Analysis of end-point with power consumption in high speed mixer.

Keijiro Terashita, Masaya Kato, Atsuo Ohike, +1

Chemical and Pharmaceutical Bulletin

High YieldsElectrical EngineeringEngineeringHigh Speed MixerMechanical Engineering +6

Formulation development of inhalation powders for FK888 with carrier lactose using Spinhaler® and its absorption in healthy volunteers

Toshiomi Nakate, H. Yoshida, Atsuo Ohike, +3

Journal of Controlled Release

Food ChemistryAllergyMedicineHealthy VolunteersFormulation Development +2

Formulation development of inhalation powders for FK888 using the E-haler® to improve the inhalation performance at a high dose, and its absorption in healthy volunteers

Toshiomi Nakate, H. Yoshida, Atsuo Ohike, +3

European Journal of Pharmaceutics and Biopharmaceutics

AsthmaAllergyHigh DoseMedicineFormulation Development +3