SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Jessie Huang, Adam J. Hume, Kristine M. Abo, +19

Cell stem cell

InflammationCytokineInflammatory Lung DiseaseLung InflammationSars-cov-2 Infection +7

Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors

Kristine M. Abo, Liang Ma, Taylor Matte, +12

SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Jessie Huang, Adam J. Hume, Kristine M. Abo, +19

Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice

Michael J. Herriges, Maria Yampolskaya, Bibek R. Thapa, +10

Cell stem cell

Regenerative MedicineDurable ReconstitutionInduced Pluripotent Stem CellLung DepositionImmunocompetent Mice +13

Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment

Kim Vanuytsel, Carlos Villacorta-Martín, Jonathan Lindstrom-Vautrin, +17

Nature Communications

Cell LineageLineage PlasticityFunctional GenomicsDevelopmental BiologyHealth Sciences +13

Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium

Kristine M. Abo, Julio Sainz de Aja, Jonathan Lindstrom-Vautrin, +14

JCI Insight

Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response

Aditya Mithal, Adam J. Hume, Jonathan Lindstrom-Vautrin, +6

Stem Cell Reports

Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes

Rhiannon B. Werder, Joseph E. Kaserman, Michael S. Packer, +6

Molecular Therapy

Cell DeathCell RegulationHepatotoxicityAntisense TherapyMolecular Diagnostics +20

CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells

Rhiannon B. Werder, Tao Liu, Kristine M. Abo, +12

Science Advances

Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme

Andrea B. Alber, Héctor Márquez, Liang Ma, +10

Nature Communications