Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells.

M Gembal, P Detimary, Patrick Gilon, +2

Journal of Clinical Investigation

Mouse B CellsCellular PhysiologyInsulin SignalingHyperpolarization (Biology)Membrane Transport +17

Interplay between cytoplasmic Ca2+ and the ATP/ADP ratio: a feedback control mechanism in mouse pancreatic islets

P Detimary, Patrick Gilon, Jean‐Claude Henquin

Biochemical Journal

Cellular PhysiologyInsulin SignalingBeta CellsMouse Pancreatic IsletsAtp/adp Ratio +18

The Changes in Adenine Nucleotides Measured in Glucose-stimulated Rodent Islets Occur in β Cells but Not in α Cells and Are Also Observed in Human Islets

P Detimary, Sandra Dejonghe, Zhidong Ling, +3

Journal of Biological Chemistry

Concentration Dependence and Time Course of the Effects of Glucose on Adenine and Guanine Nucleotides in Mouse Pancreatic Islets

P Detimary, Georges Berghe, Jean‐Claude Henquin

Journal of Biological Chemistry

Possible links between glucose-induced changes in the energy state of pancreatic B cells and insulin release. Unmasking by decreasing a stable pool of adenine nucleotides in mouse islets.

P Detimary, Jean‐Christophe Jonas, Jean‐Claude Henquin

Journal of Clinical Investigation

Metabolic SyndromeAdenine NucleotidesMedicinePhysiologyDiabetes +11

Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets

Jean‐Christophe Jonas, Timothy Plant, Patrick Gilon, +3

British Journal of Pharmacology

Stable and diffusible pools of nucleotides in pancreatic islet cells.

P Detimary, Jean‐Christophe Jonas, Jean‐Claude Henquin

Endocrinology

Protein SecretionMolecular BiologyCellular PhysiologyInsulin SignalingNucleic Acid Chemistry +18

Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells

P Detimary, Patrick Gilon, Myriam Nenquin, +1

Biochemical Journal

Glucose ControlCellular PharmacologyDistinct DependenceCellular PhysiologyInsulin Signaling +17

Multisite control of insulin release by glucose.

Jean‐Claude Henquin, M Gembal, P Detimary, +3

PubMed

Cellular PhysiologyInsulin SignalingAtp/adp RatioMetabolic EngineeringInsulin Delivery +17

Okadaic acid‐induced decrease in the magnitude and efficacy of the Ca²⁺ signal in pancreatic <i>β</i> cells and inhibition of insulin secretion

Yoshihiko Sato, Pascal Mariot, P Detimary, +2

British Journal of Pharmacology