In this paper, the actual background of the susceptible population being directly patients after inhaling a certain amount of PM2.5 is taken into account. The concentration response function of PM2.5 is introduced, and the SISP respiratory disease model is proposed. Qualitative theoretical analysis proves that the existence, local stability and global stability of the equilibria are all related to the daily emission P0 of PM2.5 and PM2.5 pathogenic threshold K. Based on the sensitivity factor analysis and time-varying sensitivity analysis of parameters on the number of patients, it is found that the conversion rate β and the inhalation rate η has the largest positive correlation. The cure rate γ of infected persons has the greatest negative correlation on the number of patients. The control strategy formulated by the analysis results of optimal control theory is as follows: The first step is to improve the clearance rate of PM2.5 by reducing the PM2.5 emissions and increasing the intensity of dust removal. Moreover, such removal work must be maintained for a long time. The second step is to improve the cure rate of patients by being treated in time. After that, people should be reminded to wear masks and go out less so as to reduce the conversion rate of susceptible people becoming patients.

#	Concept	H-Index	Publications	Citations
1	Medicine	1	1	36
2	Public Health	1	1	36
3	Epidemiology	1	1	36
4	Global Health	1	1	36
5	International Health	1	1	36

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