Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Daehwan Kim, Joseph M. Paggi, Chanhee Park, +2

Nature Biotechnology

ChromatinGeneticsGenome StructureGenome AnalysisGenomics +4

Structure of the µ-opioid receptor–Gi protein complex

Antoine Koehl, Hongli Hu, Shoji Maeda, +14

Nature

Molecular PharmacologySignal TransductionMolecular PhysiologyBiochemistryG Protein-coupled Receptor +4

Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

Eric M. Jones, Nathan B. Lubock, AJ Venkatakrishnan, +10

eLife

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

Koichiro Kishi, Yoon Seok Kim, Masahiro Fukuda, +24

Cell

Trimer InterfaceMolecular BiologyCytoskeletonOptogeneticsCellular Physiology +17

Crystal structure of the natural anion-conducting channelrhodopsin GtACR1

Yoon Seok Kim, Hideaki Kato, Keitaro Yamashita, +10

Nature

Crystal StructureBiochemistryProtein X-ray CrystallographyStructure ElucidationCrystallography +1

Insights into distinct signaling profiles of the µOR activated by diverse agonists

Qianhui Qu, Weijiao Huang, Joseph M. Paggi, +13

Nature Chemical Biology

Signal TransductionMolecular PhysiologySignaling PathwayG Protein-coupled ReceptorMedicine +7

Molecular mechanism of biased signaling at the kappa opioid receptor

Amal El Daibani, Joseph M. Paggi, Kuglae Kim, +11

Nature Communications

Structural mechanisms of selectivity and gating in anion channelrhodopsins

Hideaki Kato, Yoon Seok Kim, Joseph M. Paggi, +16

Nature

Molecular PhysiologyBiochemistryMembrane TransportBiomolecular InteractionMedicine +2

A sequence-based, deep learning model accurately predicts RNA splicing branchpoints

Joseph M. Paggi, Gill Bejerano

RNA

S-CAP extends pathogenicity prediction to genetic variants that affect RNA splicing

Karthik A. Jagadeesh, Joseph M. Paggi, James Ye, +4

Nature Genetics

Rna ProcessingGenetic VariantsFunctional GenomicsGeneticsRna Splicing +10