Scott M. Irwin

Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium tuberculosis

Emily Driver, Gavin J. Ryan, Donald R. Hoff et al. · Antimicrobial Agents and Chemotherapy · 2012 · 270 citations

Necrotic Lesions, Medical Microbiology, Pulmonary Tuberculosis +12

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with <i>Mycobacterium tuberculosis</i>

Scott M. Irwin, Emily Driver, Edward Lyon et al. · Disease Models & Mechanisms · 2015 · 185 citations · Full text

Immunology, Pathology, Inflammation +19

Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in <i>Mycobacterium tuberculosis</i> Infected C3HeB/FeJ Mice

Scott M. Irwin, Brendan Prideaux, Edward Lyon et al. · ACS Infectious Diseases · 2016 · 152 citations · Full text

Lung Inflammation, Tuberculosis Prevention, Immunology +18

Limited Activity of Clofazimine as a Single Drug in a Mouse Model of Tuberculosis Exhibiting Caseous Necrotic Granulomas

Scott M. Irwin, Veronica Gruppo, Elizabeth J. Brooks et al. · Antimicrobial Agents and Chemotherapy · 2014 · 113 citations · Full text

Lung Inflammation, Immunology, Pathology +16

Phenotypic Definition of Effector and Memory T-Lymphocyte Subsets in Mice Chronically Infected with<i>Mycobacterium tuberculosis</i>

Marcela Henao‐Tamayo, Diane Ordway, Scott M. Irwin et al. · Clinical and Vaccine Immunology · 2010 · 107 citations · Full text

Lymphocyte Development, Adaptive Immune System, Humoral Response +22