The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

Fan Yang, Xian Xiao, Bo Hyun Lee, +4

Nature Communications

A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel

Chang Liu, Rebecca M. Reese, Simon Vu, +21

Neuron

Signal TransductionMolecular PhysiologyBiochemistryNatural SciencesReceptor (Biochemistry) +7

Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers

Yue Yin, Yawen Dong, Simon Vu, +4

British Journal of Pharmacology

Rational design and validation of a vanilloid-sensitive TRPV2 ion channel

Fan Yang, Simon Vu, Vladimir Yarov‐Yarovoy, +1

Proceedings of the National Academy of Sciences

Electrical EngineeringSignal TransductionProtein AssemblyBiochemistryRational Design +13

A distinct structural mechanism underlies TRPV1 activation by piperine

Yawen Dong, Yue Yin, Simon Vu, +4

Biochemical and Biophysical Research Communications

Signal TransductionMolecular PhysiologyBiochemistryNatural SciencesMolecular Biology +4

A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds

Guangxu Du, Yuhua Tian, Zhihao Yao, +5

Journal of Biological Chemistry

New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket

Simon Vu, Vikrant Singh, Heike Wulff, +2

eLife

Permissive ConformationMolecular BiologyChemical BiologyNew Capsaicin AnalogsMolecular Recognition +14

Src Regulates Cigarette Smoke–Induced Ceramide Generation via Neutral Sphingomyelinase 2 in the Airway Epithelium

Samuel Chung, Simon Vu, Simone Filosto, +1

American Journal of Respiratory Cell and Molecular Biology

A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel

Aiqin Zhu, Aerziguli Aierken, Zhihao Yao, +5

Toxicon

Pain MedicineMedicineNeuropathic PainIon ChannelsPathology +6

Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening

Linlin Ma, Fan Yang, Simon Vu, +1

Scientific Reports