Robert Macci

Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery

Prasad V. Chaturvedula, Stephen E. Mercer, Sokhom S. Pin et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 61 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of (<i>R</i>)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-<i>N</i>-(3-(7-methyl-1<i>H</i>-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure

Andrew P. Degnan, Prasad V. Chaturvedula, Charles M. Conway et al. · Journal of Medicinal Chemistry · 2008 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists

Stephen E. Mercer, Prasad V. Chaturvedula, Charles M. Conway et al. · Bioorganic & Medicinal Chemistry Letters · 2020 · 19 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1

Xiaojun Han, Rita L. Civiello, Charles M. Conway et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 16 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability

Andrew P. Degnan, Charles M. Conway, R. A. Dalterio et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 14 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11