The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures

Carmela Parenti, Rita Turnaturi, Giuseppina Aricò, +8

Neuropharmacology

Molecular NeuroscienceMedicinePersistent PainNeuropathic PainMolecular Pain +8

Evaluation of N-substitution in 6,7-benzomorphan compounds

Lorella Pasquinucci, Orazio Prezzavento, Agostino Marrazzo, +8

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryNatural Sciences +3

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation

Carmela Parenti, Agostino Marrazzo, Giuseppina Aricò, +5

Inflammation Research

InflammationPain SyndromeAutoimmune DiseasePain MedicineMedicine +11

Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain

Carmela Parenti, Giuseppina Aricò, Giuseppe Ronsisvalle, +1

Peptides

Acute PainPain MedicineNeuropathic PainMolecular PainRat Model +14

Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand

Carmela Parenti, Rita Turnaturi, Giuseppina Aricò, +6

Life Sciences

Molecular PharmacologyPain MedicineMedicineMolecular PainNeuropharmacology +6

Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists

Silvia Franchini, Leda Ivanova Manasieva, Claudia Sorbi, +10

European Journal of Medicinal Chemistry

Molecular PharmacologyDrug TargetBiochemistryFunctional SelectivityMedicine +6

Synthesis and Resolution of<i>cis</i>-(±)-Methyl (1<i>R</i>,2<i>S</i>/1<i>S</i>,2<i>R</i>)-2-[(4-Hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(±)-PPCC)]: New σ Receptor Ligands with Neuroprotective Effect

Orazio Prezzavento, Agata Campisi, Carmela Parenti, +8

Journal of Medicinal Chemistry

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain

Nunzio Vicario, Rosalba Parenti, Giuseppina Aricò, +4

Molecular Pain

Pain TherapyPain DisordersAcute PainPain MedicineSynaptic Transmission +21

Novel Potent and Selective σ Ligands: Evaluation of Their Agonist and Antagonist Properties

Agostino Marrazzo, Enrique J. Cobos, Carmela Parenti, +10

Journal of Medicinal Chemistry

The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment

Lorella Pasquinucci, Carmela Parenti, Rita Turnaturi, +8

Life Sciences

Pain TherapyPain ResearchBenzomorphan-based Lp1 LigandHealth SciencesChronic Pain Treatment +12