Jonathan H. Sheehan

Small-molecule ligand docking into comparative models with Rosetta

Steven A. Combs, Samuel DeLuca, Stephanie H. DeLuca et al. · Nature Protocols · 2013 · 191 citations

Pharmacy, Chemistry, Medicinal Chemistry +13

<i>EGFR</i> Fusions as Novel Therapeutic Targets in Lung Cancer

Kartik Konduri, Jean‐Nicolas Gallant, Young Kwang Chae et al. · Cancer Discovery · 2016 · 140 citations · Full text

Medicine, Oncology, Pharmacology +17

<i>EGFR</i> Kinase Domain Duplication ( <i>EGFR</i> -KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib

Jean‐Nicolas Gallant, Jonathan H. Sheehan, Timothy M. Shaver et al. · Cancer Discovery · 2015 · 122 citations · Full text

Medicine, Genetics, Oncology +15

An Acquired <i>HER2</i>  T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant–Driven Breast Cancer

Ariella B. Hanker, Monica Red Brewer, Jonathan H. Sheehan et al. · Cancer Discovery · 2017 · 105 citations · Full text

Medicine, Oncology, Pharmacology +14

Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity

Ariella B. Hanker, Benjamin P. Brown, Jens Meiler et al. · Cancer Cell · 2021 · 99 citations · Full text

Medicine, Genetics, Molecular Biology +15