Jacob J. Orme

ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

Jacob J. Orme, Khalid Jazieh, Tiancheng Xie et al. · OncoImmunology · 2020 · 121 citations · Full text

Inhibitor Resistance, Tumor Biology, Medicinal Chemistry +15

Macrophage subpopulations in systemic lupus erythematosus.

Jacob J. Orme, Chandra Mohan · PubMed · 2012 · 92 citations

Immunology, Pathology, Innate Immunity +17

A noncanonical AR addiction drives enzalutamide resistance in prostate cancer

Yundong He, Ting Wei, Zhenqing Ye et al. · Nature Communications · 2021 · 85 citations · Full text

Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE

Jacob J. Orme, Yong Du, Kamala Vanarsa et al. · Clinical Immunology · 2016 · 79 citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +9

Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles

Jacob J. Orme, Elizabeth Ann L. Enninga, Fabrice Lucien-Matteoni et al. · Journal for ImmunoTherapy of Cancer · 2020 · 62 citations · Full text