Christopher T. Halsall

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88^L265P Diffuse Large B-Cell Lymphoma

James S. Scott, Sébastien L. Degorce, Rana Anjum et al. · Journal of Medicinal Chemistry · 2017 · 56 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +10

Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R)

Sébastien L. Degorce, Scott Boyd, Jon Curwen et al. · Journal of Medicinal Chemistry · 2016 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Regioselective Synthesis of 3-Hydroxy-4,5-alkyl-Substituted Pyridines Using 1,3-Enynes as Alkynes Surrogates

Manuel Barday, Kelvin Y. T. Ho, Christopher T. Halsall et al. · Organic Letters · 2016 · 29 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15

Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4

Sébastien L. Degorce, Rana Anjum, Keith Dillman et al. · Bioorganic & Medicinal Chemistry · 2018 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88^L265P Mutant Diffuse Large B Cell Lymphoma

Sébastien L. Degorce, Rana Anjum, Andrew Bloecher et al. · Journal of Medicinal Chemistry · 2019 · 20 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8