Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes

Aimon K. Alkanani, Naoko Hara, Peter A. Gottlieb, +5

Diabetes

DysbiosisImmunologyGastroenterologyPathologyType 1 +15

Prevention of Virus-Induced Type 1 Diabetes with Antibiotic Therapy

Naoko Hara, Aimon K. Alkanani, Diana Ir, +4

The Journal of Immunology

DysbiosisHost-microbe InteractionsImmunologyGut MicrobiotaAntimicrobial Chemotherapy +20

α1-Antitrypsin Therapy Downregulates Toll-Like Receptor-Induced IL-1β Responses in Monocytes and Myeloid Dendritic Cells and May Improve Islet Function in Recently Diagnosed Patients With Type 1 Diabetes

Peter A. Gottlieb, Aimon K. Alkanani, Aaron W. Michels, +4

The Journal of Clinical Endocrinology & Metabolism

Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition

Roberto Castro-Gutiérrez, Aimon K. Alkanani, Clayton E. Mathews, +2

Frontiers in Endocrinology

Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes

David A. Ostrov, Aimon K. Alkanani, Kristen A. McDaniel, +11

Journal of Clinical Investigation

Dysregulated Toll-Like Receptor–Induced Interleukin-1β and Interleukin-6 Responses in Subjects at Risk for the Development of Type 1 Diabetes

Aimon K. Alkanani, Marian Rewers, Fran Dong, +3

Diabetes

Il-6 PathwaysImmune RegulationImmunologyImmunologic MechanismCd4 T Cell Responses +27

Induction of Diabetes in the RIP-B7.1 Mouse Model Is Critically Dependent on TLR3 and MyD88 Pathways and Is Associated With Alterations in the Intestinal Microbiome

Aimon K. Alkanani, Naoko Hara, Egil Lien, +6

Diabetes

DysbiosisInnate Immune SystemImmunologyPathologyTlr Pathways +20

Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System

Sarah Mann, Zhicheng Zhou, Laurie G. Landry, +8

Frontiers in Immunology

Activated T CellsSystems BiologyCell TherapyT CellsT-regulatory Cell +13

Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes

Naoko Hara, Aimon K. Alkanani, Charles A. Dinarello, +1

Journal of Molecular Medicine

Virus-induced Proinflammatory ResponsesMetabolic SyndromeChromatinAutoimmune DiseaseHistone Deacetylase Inhibitor +8

Kilham rat virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK–STAT activation prior to insulitis

Aimon K. Alkanani, Naoko Hara, Roberto Gianani, +1

Virology

InflammationPathogenesisImmunologyDiabetesPathology +7