Christopher A. Cassa

Predictable and precise template-free CRISPR editing of pathogenic variants

Max W. Shen, Mandana Arbab, Jonathan Y. Hsu et al. · Nature · 2018 · 630 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

Akl C. Fahed, Minxian Wang, Julian R. Homburger et al. · Nature Communications · 2020 · 478 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge

Catherine A. Brownstein, Alan H. Beggs, Nils Homer et al. · Genome biology · 2014 · 432 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning

Mandana Arbab, Max W. Shen, Beverly Mok et al. · Cell · 2020 · 292 citations · Full text

Life Sciences, Data Science, Genome Editing +11

Estimating the selective effects of heterozygous protein-truncating variants from human exome data

Christopher A. Cassa, Donate Weghorn, Daniel J. Balick et al. · Nature Genetics · 2017 · 194 citations · Full text

Life Sciences, Bioinformatics, Genetics +14