Tom P. Brew

Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin–Deficient Cells

Bryony J. Telford, Augustine Chen, Henry Beetham et al. · Molecular Cancer Therapeutics · 2015 · 36 citations · Full text

Life Sciences, Molecular Biology, Oncology +16

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

Tanis Godwin, S. Thomas Kelly, Tom P. Brew et al. · Gastric Cancer · 2018 · 33 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells

Nicola Bougen‐Zhukov, Yasmin Nouri, Tanis Godwin et al. · Cancers · 2019 · 31 citations · Full text

Medicine, Cancer Biology, Oncology +16

E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors

Lyvianne Decourtye, Nicola Bougen‐Zhukov, Tanis Godwin et al. · Cancers · 2021 · 21 citations · Full text

Medicine, Genetics, Oncology +16

Modelling hereditary diffuse gastric cancer initiation using transgenic mouse‐derived gastric organoids and single‐cell sequencing

Katherine Dixon, Tom P. Brew, David Farnell et al. · The Journal of Pathology · 2021 · 19 citations

Medicine, Molecular Genetics, Oncology +17