J. A. SESNIE

The Synthesis, Structure-Activity, and Structure-Side Effect Relationships of a Series of 8-Alkoxy- and 5-Amino-8-alkoxyquinolone Antibacterial Agents

Joseph P. Sanchez, Rocco D. Gogliotti, John M. Domagala et al. · Journal of Medicinal Chemistry · 1995 · 67 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1-pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy

John M. Domagala, Susan E. Hagen, Themis E. Joannides et al. · Journal of Medicinal Chemistry · 1993 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship

John M. Domagala, Alex Bridges, Townley P. Culbertson et al. · Journal of Medicinal Chemistry · 1991 · 54 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity

Joseph P. Sanchez, Carl L. Heifetz, Steven R. Priebe et al. · Journal of Medicinal Chemistry · 1992 · 40 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships

Townley P. Culbertson, Joseph P. Sanchez, Laura Gambino et al. · Journal of Medicinal Chemistry · 1990 · 22 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12