Sayuri Yonekawa

Lysosomal abnormalities in hereditary spastic paraplegia types <scp>SPG</scp> 15 and <scp>SPG</scp> 11

Benoît Renvoisé, Jaerak Chang, Rajat Singh et al. · Annals of Clinical and Translational Neurology · 2014 · 117 citations · Full text

Life Sciences, Genetics, Neurology +12

Rapid Assembly of a Library of Lipophilic Iminosugars via the Thiol–Ene Reaction Yields Promising Pharmacological Chaperones for the Treatment of Gaucher Disease

Ethan D. Goddard‐Borger, Michael B. Tropak, Sayuri Yonekawa et al. · Journal of Medicinal Chemistry · 2012 · 79 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Synthesis of 1,5-Dideoxy-1,5-iminoribitol <i>C</i>-Glycosides through a Nitrone–Olefin Cycloaddition Domino Strategy: Identification of Pharmacological Chaperones of Mutant Human Lysosomal β-Galactosidase

Aloysius Siriwardena, Dhiraj P. Sonawane, Omprakash Bande et al. · The Journal of Organic Chemistry · 2014 · 53 citations

Life Sciences, Biochemistry, Pharmacology +10

Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo

Michael B. Tropak, Sayuri Yonekawa, Subha Karumuthil‐Melethil et al. · Molecular Therapy — Methods & Clinical Development · 2016 · 53 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

A sensitive fluorescence-based assay for monitoring GM2 ganglioside hydrolysis in live patient cells and their lysates

Michael B. Tropak, Scott Bukovac, Brigitte Rigat et al. · Glycobiology · 2009 · 28 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17