Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

Valerie A. Gerriets, Rigel J. Kishton, Marc O. Johnson, +10

Nature Immunology

InflammationSignal TransductionT-regulatory CellImmunologyToll-like Receptor +7

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

Hu Zeng, Sivan Cohen, Cliff Guy, +12

Immunity

Signal TransductionCell RegulationSignaling PathwayReceptor Tyrosine KinaseT-regulatory Cell +6

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

Rigel J. Kishton, Carson E. Barnes, Amanda Nichols, +15

Cell Metabolism

Cell PhysiologyReductive StressSignal TransductionCell RegulationBalance Glycolysis +13

Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects

Polina Stepensky, Baerbel Keller, Mary Buchta, +12

Journal of Allergy and Clinical Immunology

Primary ImmunodeficiencyAutoimmune DiseaseDisease MechanismImmunodeficienciesImmunology +8

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia

Peter J. Siska, Gerritje J. W. van der Windt, Rigel J. Kishton, +6

The Journal of Immunology

Mixed-phenotype Acute LeukemiaT-regulatory CellImmunologyImmune RegulationCell Death +16

CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells

Eszter Bakos, Christoph A. Thaiss, Matthias P. Kramer, +7

The Journal of Immunology

Adaptive Immune SystemImmune Cell MigrationT-regulatory CellImmunologyImmune Regulation +23

Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy

Hagit Salem, Inbal Rachmin, Nissan Yissachar, +5

Oncogene

InflammationCytokineSignaling PathwayReceptor Tyrosine KinaseImmunology +9

The Cytokine Midkine and Its Receptor RPTPζ Regulate B Cell Survival in a Pathway Induced by CD74

Sivan Cohen, Or-yam Shoshana, Einat Zelman-Toister, +11

The Journal of Immunology

c-Met and Its Ligand Hepatocyte Growth Factor/Scatter Factor Regulate Mature B Cell Survival in a Pathway Induced by CD74

Maya Gordin, Melania Tesio, Sivan Cohen, +5

The Journal of Immunology

A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma

Satoko Kakiuchi-Kiyota, Thorsten Ross, Heidi Ackerly Wallweber, +27

Leukemia

Hematological MalignancyTumor BiologyMalignant Blood DisorderImmunologyMultiple Myeloma +5