Sam Butterworth

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

M. Raymond V. Finlay, Mark J. Anderton, Susan Ashton et al. · Journal of Medicinal Chemistry · 2014 · 602 citations · Full text

Medicine, Oncology, Pharmacology +15

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Richard A. Ward, Mark J. Anderton, Susan Ashton et al. · Journal of Medicinal Chemistry · 2013 · 261 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A General Oxidative Cyclization of 1,5‐Dienes Using Catalytic Osmium Tetroxide

Timothy J. Donohoe, Sam Butterworth · Angewandte Chemie International Edition · 2003 · 99 citations

Natural Sciences, Chemistry, Biocatalysis +6

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Xiaodong Zhuang, Andrea Magrì, Michelle L. Hill et al. · Nature Communications · 2019 · 99 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Oxidative Cyclization of Diols Derived from 1,5‐Dienes: Formation of Enantiopure <i>cis</i>‐Tetrahydrofurans by Using Catalytic Osmium Tetroxide; Formal Synthesis of (+)‐<i>cis</i>‐Solamin

Timothy J. Donohoe, Sam Butterworth · Angewandte Chemie International Edition · 2005 · 80 citations · Full text

Natural Sciences, Chemistry, Catalysis +5