Virendra P. Shah

A thyromimetic that decreases plasma cholesterol levels without increasing cardiac activity

A. H. Underwood, J. C. EMMETT, David A. Ellis et al. · Nature · 1986 · 131 citations

Pharmacy, Endocrinology, Pharmacology +11

Thyroid hormone analogs. Synthesis of 3'-substituted 3,5-diiodo-L-thyronines and quantitative structure-activity studies of in vitro and in vivo thyromimetic activities in rat liver and heart

Paul D. Leeson, David Ellis, J. C. EMMETT et al. · Journal of Medicinal Chemistry · 1988 · 52 citations

Life Sciences, Biochemistry, Endocrinology +11

Selective thyromimetics. Cardiac-sparing thyroid hormone analogs containing 3'-arylmethyl substituents

Paul D. Leeson, John C. Emmett, Virendra P. Shah et al. · Journal of Medicinal Chemistry · 1989 · 40 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme

Andrew D. Gribble, Roland E. Dolle, Antony N. Shaw et al. · Journal of Medicinal Chemistry · 1996 · 33 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. 2. Synthesis and Evaluation of (3<i>R</i>*,5<i>S</i>*)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in Vitro and in Vivo

Andrew D. Gribble, Robert J. Ife, Antony N. Shaw et al. · Journal of Medicinal Chemistry · 1998 · 31 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14