Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer

Tania M. Puvirajesinghe, François Bertucci, Ashish Jain, +19

Nature Communications

Protein–protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

S. Betzi, Audrey Restouin, Sandrine Opi, +5

Proceedings of the National Academy of Sciences

Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1

Hassiba Chaib, Angela Nebbioso, Thomas Prébet, +6

Leukemia

Histone Methyl-transferase Suv39h1MedicineApoptosisCell DeathAnti-leukemia Activity +5

Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth

Gilles Fournier, Olivier Cabaud, Emmanuelle Josselin, +8

Oncogene

Breast OncologyPoor OutcomeMedicineTumor GrowthPathology +7

Amine−Guanidine Switch: A Promising Approach to Improve DNA Binding and Antiproliferative Activities

Keiichiro Ohara, Michaël Smietana, Audrey Restouin, +4

Journal of Medicinal Chemistry

Chemoprevention StrategyCompound 14Molecular BiologyChemical BiologyPharmaceutical Chemistry +20

Modified Cap Group Suberoylanilide Hydroxamic Acid Histone Deacetylase Inhibitor Derivatives Reveal Improved Selective Antileukemic Activity

Chanaz Salmi-Smail, Aurélie Fabre, Audrey Restouin, +6

Journal of Medicinal Chemistry

H3.3K27M Mutation Controls Cell Growth and Resistance to Therapies in Pediatric Glioma Cell Lines

Andria Rakotomalala, Quentin Bailleul, Clara Savary, +16

Cancers

Epigenetic ChangeHigh-grade GliomasCancer BiologyGliomaEpigenetics +17

Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells

Rudra Kashyap, Bart Roucourt, Frédérique Lembo, +5

Frontiers in Pharmacology

Protein–Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery

Sabine Milhas, Brigitt Raux, S. Betzi, +23

ACS Chemical Biology

Evidences for ubiquitination and intracellular trafficking of LAT, the linker of activated T cells

C. Brignatz, Audrey Restouin, G. Bonello, +2

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Activated T CellsSignal TransductionCell InteractionCell TraffickingT-regulatory Cell +8