Filipe Freire

Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead <b>MSC-4106</b>

Timo Heinrich, Carl R. Peterson, Richard Schneider et al. · Journal of Medicinal Chemistry · 2022 · 67 citations · Full text

Shedding Light on the Interaction of Human Anti-Apoptotic Bcl-2 Protein with Ligands through Biophysical and in Silico Studies

João Ramos, Jayaraman Muthukumaran, Filipe Freire et al. · International Journal of Molecular Sciences · 2019 · 31 citations · Full text

Drug Target, Apoptosis, Cell Death +22

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding

Ana Gomes, Filipa Trovão, B. Pinheiro et al. · International Journal of Molecular Sciences · 2018 · 28 citations · Full text

Mutant P53, Tumor Biology, Genome Instability +13

Solution structure, dynamics and binding studies of a family 11 carbohydrate-binding module from <i>Clostridium thermocellum</i> (<i>Ct</i>CBM11)

Aldino Viegas, João Sardinha, Filipe Freire et al. · Biochemical Journal · 2013 · 20 citations · Full text

Conservation in the mechanism of glucuronoxylan hydrolysis revealed by the structure of glucuronoxylan xylanohydrolase (<i>Ct</i>Xyn30A) from<i>Clostridium thermocellum</i>

Filipe Freire, Anil Kumar Verma, Pedro Bule et al. · Acta Crystallographica Section D Structural Biology · 2016 · 17 citations