p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

Safa Al‐Sarraj, Andrew King, Claire Troakes, +7

Acta Neuropathologica

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisNeuroanatomyNeuronal CytoplasmicDegenerative Disease +11

Cortical selective vulnerability in motor neuron disease: a morphometric study

Satomi Maekawa, Safa Al‐Sarraj, Milla Kibble, +5

Brain

NeuropsychologyMotor Neuron DiseaseNeurological DisorderPrimary Motor CortexSocial Sciences +19

An MND/ALS phenotype associated with <i>C9orf72</i> repeat expansion: Abundant p62‐positive, TDP‐43‐negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline

Claire Troakes, Satomi Maekawa, Lokesh Wijesekera, +14

Neuropathology

TDP‐43 is consistently co‐localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations

Satomi Maekawa, P. Nigel Leigh, Andrew King, +6

Neuropathology

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisMotor Neuron DiseaseMedicineGenetics +10

Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease

Andrew King, Fiona Sweeney, István Bódi, +3

Neuropathology

Corticobasal DegenerationPathologyHippocampal SclerosisNeurochemical BiomarkersDementia Pugilistica +16

Ubiquitinated, p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositive for phosphorylation-dependent TDP-43

Andrew King, Satomi Maekawa, István Bódi, +2

Neuropathology

Motor Control DisordersNeurological DisorderCorticobasal DegenerationSynaptic SignalingSocial Sciences +26

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

Tomohiro Umeda, Satomi Maekawa, Tetsuya Kimura, +3

Acta Neuropathologica

Knockout MouseNeurodegenerative DiseasesDevelopmental BiologyMolecular NeuroscienceTransgenic Mouse Models +9

Mixed tau, TDP-43 and p62 pathology in FTLD associated with a C9ORF72 repeat expansion and p.Ala239Thr MAPT (tau) variant

Andrew King, Safa Al‐Sarraj, Claire Troakes, +5

Acta Neuropathologica

C9orf72 Repeat ExpansionMendelian DisorderAutoimmune DiseaseGenetic DisorderMedicine +7

Ubiquitin‐only intraneuronal inclusion in the substantia nigra is a characteristic feature of motor neurone disease with dementia

Safa Al‐Sarraj, Satomi Maekawa, Milla Kibble, +2

Neuropathology and Applied Neurobiology

Neuromodulation TherapiesSocial SciencesNeurobiology Of DiseaseAlzheimer's DiseaseNeurology +17

Clusterin expression is upregulated following acute head injury and localizes to astrocytes in old head injury

Claire Troakes, Rachel Smyth, Farzana Noor, +4

Neuropathology

Traumatic Brain InjuryPathologyOld Head InjuryClusterin ExpressionNeuroinflammation +19