Delia Bradford

Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941

Laurent Salphati, Harvey Wong, Marcia Belvin et al. · Drug Metabolism and Disposition · 2010 · 82 citations

Medicine, Oncology, Pharmacology +16

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

Paul R. Leger, Dennis X. Hu, Bérenger Biannic et al. · Journal of Medicinal Chemistry · 2020 · 74 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity <i>In Vitro</i> and <i>In Vivo</i>

Yamini M. Ohol, Michael Sun, Gene Cutler et al. · Molecular Cancer Therapeutics · 2020 · 38 citations

Medicine, Oncology, Pharmacology +13

Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy

Jeffrey J. Jackson, Grant M. Shibuya, Buvana Ravishankar et al. · Journal of Medicinal Chemistry · 2022 · 12 citations · Full text

Medicine, Oncology, Pharmacology +16