Simon P. Kossen

Kinetic profile in blood and brain of the cholinesterase reactivating oxime HI-6 after intravenous administration to the rat

David A. Ligtenstein, Simon P. Kossen · Toxicology and Applied Pharmacology · 1983 · 62 citations

Cerebral Vascular Regulation, Intravenous Administration, Neurophysiology +12

Determination of some pyridinium aldoxime compounds by means of ion-pair reversed-phase high-performance liquid chromatography: Application in biological material

Hendrik P. Benschop, Kees A.G. Konings, Simon P. Kossen et al. · Journal of Chromatography B Biomedical Sciences and Applications · 1981 · 43 citations

Chemical Measurement, Biological Material, Biochemistry +10

In vivo distribution of organophosphate antidotes: Autoradiography of [14C]HI-6 in the rat

David A. Ligtenstein, Gerrit W.H. Moes, Simon P. Kossen · Toxicology and Applied Pharmacology · 1988 · 24 citations

Molecular Pharmacology, Organophosphate Antidotes, Vivo Distribution +5

Stereospecific reactivation of human brain and erythrocyte acetylcholinesterase inhibited by 1,2,2,-trimethylpropyl methylphosphonofluoridate (soman)

Leo P.A. De Jong, Simon P. Kossen · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · 1985 · 22 citations

Inhibitory Activity, Neurophysiology, Medicine +11

Identification of two metabolites of the cholinesterase reactivator HI-6 isolated from rat urine

David A. Ligtenstein, E.R.J. Wils, Simon P. Kossen et al. · Journal of Pharmacy and Pharmacology · 1987 · 11 citations

Secondary Metabolite, Pharmaceutical Chemistry, Medicinal Chemistry +16