Ken Higashimoto

Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer

Tetsuji Nakagawachi, Hidenobu Soejima, Takeshi Urano et al. · Oncogene · 2003 · 180 citations

Histone Modifications, Chromatin, Cpg Island Hypermethylation +12

Expression profile of <i>LIT1/KCNQ1OT1</i> and epigenetic status at the KvDMR1 in colorectal cancers

Seiji Nakano, Kazuhiro Murakami, Makiko Meguro et al. · Cancer Science · 2006 · 101 citations · Full text

Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome

Eri Imagawa, Ken Higashimoto, Yasunari Sakai et al. · Human Mutation · 2017 · 101 citations

Histone Modifications, Epigenetic Change, Genetics +19

Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1

Ken Higashimoto, Peter Kühn, Dhaval Desai et al. · Proceedings of the National Academy of Sciences · 2007 · 100 citations · Full text

Histone Methylation Activity, Molecular Regulation, Epigenetic Change +16

Ash1l Methylates Lys36 of Histone H3 Independently of Transcriptional Elongation to Counteract Polycomb Silencing

Hitomi Miyazaki, Ken Higashimoto, Yukari Yada et al. · PLoS Genetics · 2013 · 85 citations · Full text

Histone Modifications, Histone H3, Retinoic Acid Receptor +19