Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology

Tino Felka, Miriam Rothdiener, S. Bast, +15

Osteoarthritis and Cartilage

MechanobiologyMusculoskeletal ResearchEngineeringBiomechanicsVitro Methodology +11

Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems

Miriam Rothdiener, Dafne Müller, Patricia Garrido Castro, +5

Journal of Controlled Release

Cell-based Drug DeliveryNanomedicineLiposomal Carrier SystemsImmunologyTargeted Drug Delivery +7

Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL)

Julia Beuttler, Miriam Rothdiener, Dafne Müller, +2

Bioconjugate Chemistry

EngineeringAffibody MoleculesTumor CellsExtracellular MicrovesiclesAffibody Liposomes +14

The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces

Tatiana Uynuk‐Ool, Miriam Rothdiener, Brandan Walters, +11

Journal of Tissue Engineering and Regenerative Medicine

Tissue EngineeringEngineeringMultiscale MechanicsGeometrical ShapeQuantitative Shape Descriptors +22

Engineering the geometrical shape of mesenchymal stromal cells through defined cyclic stretch regimens

Brandan Walters, Tatiana Uynuk‐Ool, Miriam Rothdiener, +4

Scientific Reports

Antibody Targeting of Nanoparticles to Tumor-Specific Receptors: Immunoliposomes

Miriam Rothdiener, Julia Beuttler, Sylvia K. E. Messerschmidt, +1

Methods in molecular biology

Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition

Miriam Rothdiener, Miriam Hegemann, Tatiana Uynuk‐Ool, +13

Scientific Reports

Tissue EngineeringStiffness-customized Collagen TypeBiomimetic MaterialsEngineeringBiofabrication +24

Onset of preclinical osteoarthritis: The angular spatial organization permits early diagnosis

Bernd Rolauffs, Miriam Rothdiener, Christian Bahrs, +7

Arthritis & Rheumatism

Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical, and structural impairment

Bernd Rolauffs, Bodo Kurz, Tino Felka, +9

Journal of Structural Biology

MechanobiologyTissue EngineeringStress-vs-time SignalsCatastrophic EventsDevelopmental Biology +10

Human osteoarthritic chondrons outnumber patient‐ and joint‐matched chondrocytes in hydrogel culture—Future application in autologous cell‐based OA cartilage repair?

Miriam Rothdiener, Tatiana Uynuk‐Ool, Norbert P. Südkamp, +4

Journal of Tissue Engineering and Regenerative Medicine