Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Malcolm C. Roberts, Ioanna Sevastou, Yoichi Imaizumi, +19

Acta Neuropathologica Communications

Study of neuroprotection of donepezil, a therapy for Alzheimer's disease

Shigeru Akasofu, M. Kimura, Takashi Kosasa, +2

Chemico-Biological Interactions

Alzheimer's DiseaseMedicineDementiaNeuropharmacologyFrontotemporal Dementia +8

Purification and Characterization of a Src-related p57 Protein-tyrosine Kinase from Xenopus Oocytes

Ken‐ichi Sato, Mamoru Aoto, Kiyotoshi Mori, +4

Journal of Biological Chemistry

Protective effect of donepezil against Aβ(1-40) neurotoxicity in rat septal neurons

M. Kimura, Shigeru Akasofu, Hiroo Ogura, +1

Brain Research

Neurodegenerative DiseasesRat Septal NeuronsMedicineNeuropharmacologyProtective Effect +7

Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen–glucose deprivation

Shigeru Akasofu, Takashi Kosasa, M. Kimura, +1

European Journal of Pharmacology

Rat Cortical NeuronsNeurophysiologyPhysiologyProtective EffectSocial Sciences +8

Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation

Carsten T. Beuckmann, Takashi Ueno, Makoto Nakagawa, +2

SLEEP

PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo

Michiaki Okuda, Ichiro Hijikuro, Yuki Fujita, +12

PLoS ONE

Motor DysfunctionSarkosyl-insoluble Aggregated TauMolecular BiologyNeurochemical BiomarkersCytoskeleton +18

Protective effect of donepezil in primary-cultured rat cortical neurons exposed to N-methyl-d-aspartate (NMDA) toxicity

Shigeru Akasofu, M. Kimura, Takashi Kosasa, +2

European Journal of Pharmacology

NeurophysiologyMedicineProtective EffectToxicologyNeuroprotection +6

Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine

Shigeru Akasofu, Kohei Sawada, Takashi Kosasa, +3

European Journal of Pharmacology

Cortical NeuronsMembrane DepolarizationNeurophysiologyMedicineNeuropharmacology +8