William W. Bachovchin

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

Marian C. Okondo, Darren C. Johnson, Ramya Sridharan et al. · Nature Chemical Biology · 2016 · 305 citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Nitrogen-15 nuclear magnetic resonance spectroscopy. The state of histidine in the catalytic triad of .alpha.-lytic protease. Implications for the charge-relay mechanism of peptide-bond cleavage by serine proteases

William W. Bachovchin, John D. Roberts · Journal of the American Chemical Society · 1978 · 233 citations

Life Sciences, Biochemistry, Chemistry +17

A Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Proteases? Theory Versus Experiment

Elissa L. Ash, James L. Sudmeier, Edward C. De Fabo et al. · Science · 1997 · 178 citations

Life Sciences, Biochemistry, Chemistry +17

Nitrogen-15 NMR spectroscopy of hydrogen-bonding interactions in the active site of serine proteases: evidence for a moving histidine mechanism

William W. Bachovchin · Biochemistry · 1986 · 178 citations

Natural Sciences, Biochemistry, Chemistry +15

Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function.

George R. Flentke, Brigitte T. Huber, Andrew G. Plaut et al. · Proceedings of the National Academy of Sciences · 1991 · 169 citations

Life Sciences, Biochemistry, Immunology +14