Donna-Michelle Smith

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

Charles Massie, Andy G. Lynch, Antonio Ramos‐Montoya et al. · The EMBO Journal · 2011 · 632 citations · Full text

Medicine, Endocrinology, Oncology +14

Identification of <i>N</i>-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1<i>H</i>-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design

Paul G. Wyatt, Andrew Woodhead, Valério Berdini et al. · Journal of Medicinal Chemistry · 2008 · 341 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Andrew Woodhead, Hayley C. Angove, Maria G. Carr et al. · Journal of Medicinal Chemistry · 2010 · 263 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines

Matthew Squires, Ruth E. Feltell, Nicola G. Wallis et al. · Molecular Cancer Therapeutics · 2009 · 172 citations

Medicine, Medicinal Chemistry, Oncology +15

A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors

Daruka Mahadevan, Ruth Plummer, Matthew Squires et al. · Annals of Oncology · 2011 · 88 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15