Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway

Yanhong Xing, Xiangqing Wei, Yucheng Liu, +14

Autophagy

Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy

Yanhong Xing, Zhongheng Sui, Yucheng Liu, +14

Basic Research in Cardiology

InflammationCardiac MuscleMitophagyHeart FailureMolecular Physiology +13

Highly enantioselective Friedel–Crafts alkylation reaction catalyzed by rosin-derived tertiary amine–thiourea: synthesis of modified chromanes with anticancer potency

Xianxing Jiang, Lipeng Wu, Yanhong Xing, +4

Chemical Communications

Anticancer PotencyAsymmetric CatalysisMedicinal ChemistryEnantioselective SynthesisPreliminary Biological Evaluation +12

MCOLN1/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc influx

Jiansong Qi, Yanhong Xing, Yucheng Liu, +19

Autophagy

A New Class of Highly Potent and Selective Endomorphin-1 Analogues Containing α-Methylene-β-aminopropanoic Acids (Map)

Yuan Wang, Yanhong Xing, Xin Liu, +7

Journal of Medicinal Chemistry

Bioorganic ChemistryOrganic ChemistryPeptide SciencePharmacotherapyChemical Biology +18

TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis

Yucheng Liu, Xinyan Wang, Wucheng Zhu, +6

Cancer Letters

Cell AutophagyMitophagyApoptosisAutophagyTrpml1-induced Autophagy Inhibition +4

Design, Synthesis, and Pharmacological Characterization of Novel Endomorphin-1 Analogues as Extremely Potent μ-Opioid Agonists

Xin Liu, Yuan Wang, Yanhong Xing, +8

Journal of Medicinal Chemistry

Pharmacological CharacterizationNew Em-1 AnaloguesPeptide SciencePharmacotherapyChemical Biology +18

Effects of Tetramethylpyrazine on Neuronal Apoptosis in the Superficial Dorsal Horn in a Rat Model of Neuropathic Pain

Yufang Leng, Xiang-Mei Gao, Wang Shu-xiu, +1

The American Journal of Chinese Medicine

Peripheral Nerve InjuryPain MedicineNeuropathic PainMolecular PainRat Model +15

Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy

Yanhong Xing, Xiangqing Wei, Mengmeng Wang, +17

Cancer Letters

Tumor BiologyCell AutophagyCancer Cell ProliferationSignaling PathwayMedicine +7

Anticancer effects of a novel class rosin-derivatives with different mechanisms

Yanhong Xing, Wei Zhang, Jingjing Song, +3

Bioorganic & Medicinal Chemistry Letters

Tumor BiologyMedicinal ChemistryChemoprevention StrategyMedicineNovel Class Rosin-derivatives +7