Nobuyasu Okita

Highly Efficient Chemoenzymatic Synthesis of Methyl (<i>R</i>)‐<i>o</i>‐Chloromandelate, a Key Intermediate for Clopidogrel, <i>via</i> Asymmetric Reduction with Recombinant <i>Escherichia coli</i>

Tadashi Ema, Sayaka Ide, Nobuyasu Okita et al. · Advanced Synthesis & Catalysis · 2008 · 97 citations

Engineering, Chemistry, Medicinal Chemistry +8

Asymmetric reduction of ketones using recombinant E. coli cells that produce a versatile carbonyl reductase with high enantioselectivity and broad substrate specificity

Tadashi Ema, Hideo Yagasaki, Nobuyasu Okita et al. · Tetrahedron · 2006 · 79 citations

Life Sciences, Biochemistry, Biotechnology +17

Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: toward practical and green access to clopidogrel

Tadashi Ema, Nobuyasu Okita, Sayaka Ide et al. · Organic & Biomolecular Chemistry · 2007 · 51 citations

Pharmacy, Chemistry, Medicinal Chemistry +10

Asymmetric reduction of a variety of ketones with a recombinant carbonyl reductase: identification of the gene encoding a versatile biocatalyst

Tadashi Ema, Hideo Yagasaki, Nobuyasu Okita et al. · Tetrahedron Asymmetry · 2005 · 36 citations

Engineering, Biochemistry, Biotechnology +16