Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

James S. Scott, Amber Balazs, Bernard Barlaam, +42

Journal of Medicinal Chemistry

Tricyclic Indazoles—A Novel Class of Selective Estrogen Receptor Degrader Antagonists

James S. Scott, Andrew Bailey, David Buttar, +16

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryDerivativesMedicineHormonal Receptor +13

C(sp³)–C(sp³) coupling of non-activated alkyl-iodides with electron-deficient alkenes <i>via</i> visible-light/silane-mediated alkyl-radical formation

Sanesh Mistry, Roopender Kumar, Andrew Lister, +1

Chemical Science

Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement

Bernard Barlaam, Chris De Savi, Allan Dishington, +26

Journal of Medicinal Chemistry

From libraries to candidate: The discovery of new ultra long-acting dibasic β2-adrenoceptor agonists

Lilian Alcaraz, Andrew Bailey, Elaine Cadogan, +14

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicinePhysiologyReceptor (Biochemistry) +6

Synthesis of a Novel Type of 2,3′‐BIMs via Platinum‐Catalysed Reaction of Indolylallenes with Indoles

Lisa E. Cooper, José M. Alonso, Louise Eagling, +7

Chemistry - A European Journal

Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

James S. Scott, Bernard Barlaam, Paul R. J. Davey, +11

ACS Medicinal Chemistry Letters

Late Stage FunctionalizationPharmaceutical ScienceBioorganic ChemistryOrganic ChemistryOral Serd Azd9833 +15

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists

James S. Scott, Darren Stead, Bernard Barlaam, +39

Journal of Medicinal Chemistry

Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release

Pasquale A. Morese, Nahoum G. Anthony, Michael S. Bodnarchuk, +12

Journal of Medicinal Chemistry

NanotherapeuticsTargeted DeliveryThiol AdditionEgfr-mediated Covalent BindingPharmaceutical Chemistry +16

Enantioconvergent nucleophilic substitution via synergistic phase-transfer catalysis

C. J. Dooley, Francesco Ibba, Bence B. Botlik, +7

Nature Catalysis