Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation

Emily H. Pilkington, May C. Lai, Xinwei Ge, +11

Biomacromolecules

EngineeringBiomimetic MaterialsBiomedical EngineeringProtein NanoparticlesMixed Biopolymers +16

β-barrel Oligomers as Common Intermediates of Peptides Self-Assembling into Cross-β Aggregates

Yunxiang Sun, Xinwei Ge, Yanting Xing, +2

Scientific Reports

Islet Amyloid Polypeptide Promotes Amyloid-Beta Aggregation by Binding-Induced Helix-Unfolding of the Amyloidogenic Core

Xinwei Ge, Ye Yang, Yunxiang Sun, +2

ACS Chemical Neuroscience

Distinct oligomerization and fibrillization dynamics of amyloid core sequences of amyloid-beta and islet amyloid polypeptide

Yunxiang Sun, Bo Wang, Xinwei Ge, +1

Physical Chemistry Chemical Physics

Distinct OligomerizationBiophysical ModelingProtein AssemblyAmyloid AggregationMolecular Biology +17

Nanoscale inhibition of polymorphic and ambidextrous IAPP amyloid aggregation with small molecules

Aleksandr Käkinen, Jozef Adamčík, Bo Wang, +5

Nano Research

Structures and dynamics of β-barrel oligomer intermediates of amyloid-beta16-22 aggregation

Xinwei Ge, Yunxiang Sun, Feng Ding

Biochimica et Biophysica Acta (BBA) - Biomembranes

β-Barrel Oligomer IntermediatesProtein AssemblyProtein FoldingNatural SciencesMolecular Biology +5

Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding

Bo Wang, Thomas Blin, Aleksandr Käkinen, +7

Polymer Chemistry

Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Xinwei Ge, Aleksandr Käkinen, Esteban N. Gurzov, +9

Chemical Communications

Molecular BiologyProtein Phase SeparationProtein FoldingBeta-cell GranulesIapp Aggregation +14

A Thermodynamics Model for the Emergence of a Stripe‐like Binary SAM on a Nanoparticle Surface

Xinwei Ge, Pu Chun Ke, Thomas P. Davis, +1

Small

EngineeringMolecular Self-assemblyNanostructured SurfaceThermodynamics ModelChemistry +17