Mutually Synergistic Nanoparticles for Effective Thermo‐Molecularly Targeted Therapy

Huanhuan Luo, Qiaoli Wang, Yibin Deng, +8

Advanced Functional Materials

NanoparticlesNanotherapeuticsEngineeringBiomedical EngineeringTumor Biology +18

Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms.

Huamiao Wang, Li Nan, Dong Soo Yu, +2

PubMed

Antisense Anti-mdm2 OligonucleotidesBreast OncologyHuman Breast CancerMdm2 ExpressionTumor Biology +15

Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists

Ekambar R. Kandimalla, Lakshmi Bhagat, Yukui Li, +7

Proceedings of the National Academy of Sciences

Cytosine-phosphate-2′-deoxy-7-deazaguanosine MotifAdaptive Immune SystemInnate Immune SystemImmunologyImmunologic Mechanism +16

Conjugation of Ligands at the 5‘-End of CpG DNA Affects Immunostimulatory Activity

Ekambar R. Kandimalla, Lakshmi Bhagat, Dong Soo Yu, +3

Bioconjugate Chemistry

A Toll-Like Receptor 7, 8, and 9 Antagonist Inhibits Th1 and Th17 Responses and Inflammasome Activation in a Model of IL-23-Induced Psoriasis

Weiwen Jiang, Fu‐Gang Zhu, Lakshmi Bhagat, +5

Journal of Investigative Dermatology

Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed‐backbone antisense oligonucleotides: In vitro and in vivo activities and mechanisms

Hui Wang, Dong Soo Yu, Sudhir Agrawal, +1

The Prostate

Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8

Tao Lan, Ekambar R. Kandimalla, Dong Soo Yu, +10

Proceedings of the National Academy of Sciences

Simra CompoundsInnate Immune SystemImmunologyHuman Tlr7Innate Immunity +16

Effect of chemical modifications of cytosine and guanine in a cpg-motif of oligonucleotides: structure–immunostimulatory activity relationships

Ekambar R. Kandimalla, Dong Soo Yu, Qiuyan Zhao, +1

Bioorganic & Medicinal Chemistry

Structure–immunostimulatory Activity RelationshipsNucleic Acid ChemistrySignal TransductionBiochemistryNatural Sciences +5

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9

Ekambar R. Kandimalla, Lakshmi Bhagat, Daqing Wang, +4

Nucleic Acids Research

Modifications Incorporated in CpG Motifs of Oligodeoxynucleotides Lead to Antagonist Activity of Toll-like Receptors 7 and 9

Dong Soo Yu, Daqing Wang, Fu‐Gang Zhu, +4

Journal of Medicinal Chemistry

ImmunologyImmune RegulationMolecular BiologyImmunologic MechanismModified Odns +18