Wolfgang Schwabe

Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared with controls.

Martin Kristian Raida, Wolfgang Schwabe, Peter Häusler et al. · PubMed · 2001 · 232 citations

Life Sciences, Genetics, Oncology +17

Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil.

Marko Kornmann, Wolfgang Schwabe, Silvia Sander et al. · PubMed · 2003 · 157 citations

Medicine, Molecular Biology, Oncology +15

Lymph Node Status and <i>TS</i> Gene Expression Are Prognostic Markers in Stage II/III Rectal Cancer After Neoadjuvant Fluorouracil-Based Chemoradiotherapy

Torsten Liersch, Claus Langer, B. Michael Ghadimi et al. · Journal of Clinical Oncology · 2006 · 85 citations

Medicine, Oncology, Radiation Oncology +13

Evaluation of 5-Fluorouracil Pharmacokinetics in Cancer Patients with a C.1905+1G&gt;A Mutation in DPYD by Means of a Bayesian Limited Sampling Strategy

André B. P. Kuilenburg, Peter Häusler, Andreas Schalhorn et al. · Clinical Pharmacokinetics · 2012 · 82 citations

Pharmacy, Oncology, Pharmacokinetics +13

Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5‐FU‐based neo‐adjuvant chemoradiotherapy in rectal cancer

Christiane Jakob, Daniela E. Aust, W. Meyer et al. · The Journal of Pathology · 2004 · 58 citations

Medicine, Oncology, Surgery +17