Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling

Pierre Guihard, Yannic Danger, Bénédicte Brounais, +9

Stem Cells

Bone ResorptionAdult Stem CellImmunologyImmune RegulationRenal Inflammation +28

The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets

Emmanuelle David, Frédéric Blanchard, Marie‐Françoise Heymann, +4

Sarcoma

Bone NicheBone RepairPathologySpecific Bone NicheDrug Resistance Patterns +14

New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance

David Monderer, Alexandrine Luseau, Amélie Bellec, +14

Laboratory Investigation

Developmental BiologyBone Morphogenic ProteinPhysiologyHuman TissueMouse Models +5

Oncostatin M Is a Growth Factor for Ewing Sarcoma

Emmanuelle David, Franck Tirode, Marc Baud’huin, +7

American Journal Of Pathology

Tumor BiologyEwing SarcomaOncogenic AgentPathologyMedicine +2

Direct anti‐cancer effect of oncostatin M on chondrosarcoma

Emmanuelle David, Pierre Guihard, Bénédicte Brounais, +10

International Journal of Cancer

Tumor BiologyOncostatin MSclerostinBone Morphogenic ProteinMalignant Disease +13

Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells

Bénédicte Brounais, Emmanuelle David, Céline Chipoy, +8

Bone

SclerostinBone Morphogenic ProteinMedicineCalvaria CellsM Treatment Induces +5

Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma: in vitro and in vivo preclinical studies

Caroline Peyrode, Valérie Weber, Emmanuelle David, +10

Investigational New Drugs

Vivo Preclinical StudiesQuaternary Ammonium-melphalan ConjugatePolymer-drug ConjugateMedicinePharmacology +7

12b80 – Hydroxybisphosphonate Linked Doxorubicin: Bone Targeted Strategy for Treatment of Osteosarcoma

Emmanuelle David, Sébastien Cagnol, Jean-Yves Goujon, +11

Bioconjugate Chemistry