Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology

Amy M. Smith, Stergios Tsartsalis, Combiz Khozoie, +9

Acta Neuropathologica

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Justin Rustenhoven, Amy M. Smith, Leon Smyth, +14

Molecular Neurodegeneration

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

Erik Nutma, Nurun Fancy, Maria Weinert, +47

Nature Communications

The transcription factor PU.1 is critical for viability and function of human brain microglia

Amy M. Smith, Hannah M. Gibbons, Robyn Oldfield, +4

Glia

M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia

Amy M. Smith, Hannah M. Gibbons, Robyn Oldfield, +5

Journal of Neuroinflammation

Isolation of highly enriched primary human microglia for functional studies

Justin Rustenhoven, Thomas Park, Patrick Schweder, +11

Scientific Reports

Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases

Rahel Feleke, Regina H. Reynolds, Amy M. Smith, +9

Acta Neuropathologica

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease

Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, +22

Nature Communications

Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures

Hannah M. Gibbons, Amy M. Smith, H. Heng Teoh, +4

Neurobiology of Disease

InflammationGliomaMedicineApoptosisPharmacology +9

Adult Human Glia, Pericytes and Meningeal Fibroblasts Respond Similarly to IFNy but Not to TGFβ1 or M-CSF

Amy M. Smith, E. Scott Graham, Sheryl Feng, +6

PLoS ONE

ImmunologyImmune RegulationPathologyImmunologic MechanismInnate Immunity +26