MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Vincenzo Summa, Steven W. Ludmerer, John A. McCauley, +22

Antimicrobial Agents and Chemotherapy

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Steven J. Harper, John A. McCauley, Michael T. Rudd, +32

ACS Medicinal Chemistry Letters

ImmunologyMolecular BiologyPharmacotherapyAntiviral DrugMedicinal Chemistry +17

Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

John A. McCauley, Charles McIntyre, Michael T. Rudd, +19

Journal of Medicinal Chemistry

ImmunologyAntiviral DrugMedicinal ChemistryViral HepatitisAntiviral Drug Development +15

MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease

Nigel J. Liverton, Steven S. Carroll, Jillian DiMuzio, +11

Antimicrobial Agents and Chemotherapy

ImmunologyMolecular BiologyAntiviral DrugExcellent SelectivityViral Hepatitis +15

Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils

Donald G. Raible, Edward S. Schulman, Jillian DiMuzio, +2

The Journal of Immunology

Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease

Nigel J. Liverton, M. Katharine Holloway, John A. McCauley, +14

Journal of the American Chemical Society

Molecular DockingMedicinal ChemistryInitial CompoundsAntiviral CompoundBiochemistry +12

Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases

Craig A. Coburn, Shawn J. Stachel, Yue‐Ming Li, +20

Journal of Medicinal Chemistry

Protein SecretionProtein AssemblyMolecular BiologyAspartyl ProteasesChemical Biology +14

Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth

Tayeba Khan, Hans Weber, Jillian DiMuzio, +10

Molecular Therapy — Nucleic Acids

BACE-1 inhibition by a series of ψ[CH2NH] reduced amide isosteres

Craig A. Coburn, Shawn J. Stachel, Kristen G. Jones, +15

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPharmaceutical ChemistryBiochemistryMedicineNatural Sciences +8

Biochemical and cell-based assays for characterization of BACE-1 inhibitors

Beth Pietrak, Ming‐Chih Crouthamel, Katherine Tugusheva, +13

Analytical Biochemistry

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +6