Brock J. Sishc

Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

Sophia B. Chernikova, Olga V. Razorenova, John Higgins et al. · Cancer Research · 2012 · 141 citations · Full text

Histone Modifications, Chromosomal Instability, Genetics +20

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe

Amanda K. Ashley, Meena Shrivastav, Jingyi Nie et al. · DNA repair · 2014 · 137 citations · Full text

Genome Instability, Cell Regulation, Cell Division +11

Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines

Narasimha Kumar Karanam, Srinivasan Kalayarasan, Lianghao Ding et al. · Cell Death and Disease · 2017 · 127 citations · Full text

Radiation Effect, Cell Death, Pathology +16

Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis

Brock J. Sishc, Christopher B. Nelson, Miles J. McKenna et al. · Frontiers in Oncology · 2015 · 68 citations · Full text

Telomere Length Maintenance, Dna Damage, Radiation Effect +22

Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

Brock J. Sishc, Lianghao Ding, Taek‐Keun Nam et al. · Science Translational Medicine · 2021 · 49 citations · Full text