Nuclear Tau, a Key Player in Neuronal DNA Protection

Audrey Sultan, Fabrice Nesslany, Marie Violet, +11

Journal of Biological Chemistry

GeneticsMolecular BiologyCell DeathOxidative StressAlzheimer's Disease +15

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

Meryem Tardivel, Séverine Bégard, Luc Bousset, +5

Acta Neuropathologica Communications

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

Simon Dujardin, Katia Lécolle, Raphaëlle Caillierez, +11

Acta Neuropathologica Communications

Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

Kevin Richetin, Pascal Steullet, Mathieu Pachoud, +16

Nature Neuroscience

Memory DeficitsSynaptic PlasticityNeurodegenerative DiseasesNeurobiology Of DiseaseAlzheimer's Disease +9

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

Simon Dujardin, Séverine Bégard, Raphaëlle Caillierez, +12

PLoS ONE

Protein SecretionPlasma Membrane-originating VesiclesTau PathologyMolecular BiologyCytoskeleton +20

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody

Marie Albert, Georges Mairet‐Coello, Clément Danis, +12

Brain

Tau SeedsTau PathologyImmunologyImmunodominancePathology +20

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin

Zeyni Mansuroglu, Houda Benhelli‐Mokrani, Vasco Marcato, +14

Scientific Reports

Different tau species lead to heterogeneous tau pathology propagation and misfolding

Simon Dujardin, Séverine Bégard, Raphaëlle Caillierez, +11

Acta Neuropathologica Communications

Cell delivery, intracellular trafficking and expression of an integrin-mediated gene transfer vector in tracheal epithelial cells

Morvane Colin, Marielle Maurice, Germain Trugnan, +8

Gene Therapy

Cell DeliveryTracheal Epithelial CellsCell TraffickingImmunologyCell-matrix Interaction +8

Invited review: Animal models of tauopathies and their implications for research/translation into the clinic

Simon Dujardin, Morvane Colin, Luc Buée

Neuropathology and Applied Neurobiology