David C. Pike

Phosphonate analogues of pyruvate. Probes of substrate binding to pyruvate oxidase and other thiamin pyrophosphate-dependent decarboxylases

T. O’Brien, Ronald Kluger, David C. Pike et al. · Biochimica et Biophysica Acta (BBA) - Enzymology · 1980 · 63 citations

Life Sciences, Biochemistry, Molecular Biology +14

Synthesis and crystal structure of an analog of 2-(.alpha.-lactyl)thiamin, racemic methyl 2-hydroxy-2-(2-thiamin)ethylphosphonate chloride trihydrate. A conformation for a least-motion, maximum-overlap mechanism for thiamin catalysis

August Turano, William Furey, J. Pletcher et al. · Journal of the American Chemical Society · 1982 · 42 citations

Natural Sciences, Biochemistry, Chemistry +7

Hydration of acylimidazoles: tetrahedral intermediates in acylimidazole hydrolysis and nucleophilic attack by imidazole on esters. The question of concerted mechanisms for acyl transfers

J. Peter Guthrie, David C. Pike · Canadian Journal of Chemistry · 1987 · 36 citations

Natural Sciences, Biochemistry, Chemistry +16

Equilibrium constants and heats of formation of methyl esters and <i>N</i>,<i>N</i>-dimethyl amides of substituted benzoic acids

J. Peter Guthrie, David C. Pike, Yiu-Chung Lee · Canadian Journal of Chemistry · 1992 · 22 citations

Natural Sciences, Biochemistry, Chemistry +14

Chemical synthesis of a proposed enzyme-generated "reactive intermediate analog" derived from thiamin diphosphate. Self-activation of pyruvate dehydrogenase by conversion of the analog to its components

Ronald Kluger, David C. Pike · Journal of the American Chemical Society · 1979 · 21 citations

Life Sciences, Biochemistry, Chemistry +5