Juan Tu

A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold:  Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based Inhibitors

Rongze Kuang, Jeffrey B. Epp, Sumei Ruan et al. · Journal of the American Chemical Society · 1999 · 55 citations

Life Sciences, Biochemistry, Medicinal Chemistry +11

Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

Rongze Kuang, Jeffrey B. Epp, Sumei Ruan et al. · Bioorganic & Medicinal Chemistry · 2000 · 51 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide

Shu He, Rongze Kuang, R. Venkataraman et al. · Bioorganic & Medicinal Chemistry · 2000 · 34 citations

Life Sciences, Medicinal Chemistry, Pharmacology +11

Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

William C. Groutas, Shu He, Rongze Kuang et al. · Bioorganic & Medicinal Chemistry · 2001 · 33 citations

Pharmacy, Medicinal Chemistry, Pharmacology +7

Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

William C. Groutas, Norman M. Schechter, Shu He et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 32 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11