Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

Emilio P. Mottillo, Eric M. Desjardins, Justin D. Crane, +13

Cell Metabolism

ObesityMetabolic SyndromeHepatologyMetabolic DisorderLiver Physiology +13

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

Serge Ducommun, Mária Deák, David Sumpton, +8

Cellular Signalling

Ampk TargetsCellular Ampk TargetsNovel Ampk SubstratesMolecular BiologyMetabolic Remodeling +19

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

Hong Yu Wang, Serge Ducommun, Chao Quan, +6

Biochemical Journal

Composite EffectsMetabolic DisorderImmunologyInsulin SignalingObesity +20

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

Serge Ducommun, Rebecca J. Ford, Laurent Bultot, +5

American Journal of Physiology-Endocrinology and Metabolism

Downstream Ampk TargetsAmpk ActivityCellular PhysiologyInsulin SignalingSignaling Pathway +21

Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle

Iori Sakakibara, Maud Wurmser, Matthieu Dos Santos, +6

Skeletal Muscle

Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

Jorge C. Correia, Yildiz Kelahmetoglu, Paulo R. Jannig, +15

Cell Metabolism

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

Qiaoli Chen, Bingxian Xie, Sangsang Zhu, +10

Diabetologia

Metabolic SyndromeEnergy HomeostasisMolecular PhysiologyExerciseExercise Physiology +10

The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

Eric M. Desjardins, Brennan K. Smith, Emily A. Day, +10

Proceedings of the National Academy of Sciences

MitophagyAmpkβ1 Ser108Ampk ActivityMetabolic RemodelingOxidative Stress +21

Thr⁶⁴⁹Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle

Serge Ducommun, Hong Yu Wang, Kei Sakamoto, +2

American Journal of Physiology-Endocrinology and Metabolism

Insulin SignalingCellular PhysiologyMouse MuscleSkeletal MuscleMetabolic Signaling +16

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

Serge Ducommun, Mária Deák, Anja Zeigerer, +10

Cellular Signalling