Characterization of a novel aquaretic agent, OPC‐31260, as an orally effective, nonpeptide vasopressin V₂ receptor antagonist

Yoshitaka Yamamura, Hidenori Ogawa, Hiroshi Yamashita, +9

British Journal of Pharmacology

OPC-41061, a Highly Potent Human Vasopressin V2-Receptor Antagonist: Pharmacological Profile and Aquaretic Effect by Single and Multiple Oral Dosing in Rats

Yoshitaka Yamamura, Shigeki Nakamura, S. Itoh, +13

Journal of Pharmacology and Experimental Therapeutics

OPC-21268, an Orally Effective, Nonpeptide Vasopressin V1 Receptor Antagonist

Yoshitaka Yamamura, Hidenori Ogawa, Tomihiko Chihara, +6

Science

HypertensionHeart FailureArginine VasopressinFunctional SelectivityMedicine +12

The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions

Akito Tanoue, Shuji Ito, Kenji Honda, +5

Journal of Clinical Investigation

Pituitary CellsGastrointestinal Peptide HormoneAdrenal GlandPituitary GlandNeuroendocrine Mechanism +15

Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A- and phosphatidylinositol 3-kinase/Akt-dependent mechanism

Ayako Hashimoto, Goro Miyakoda, Yoshimi Hirose, +1

Atherosclerosis

InflammationMolecular PharmacologyMolecular PhysiologySignal TransductionReactive Nitrogen Specie +12

The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions

Akito Tanoue, Shuji Ito, Kenji Honda, +5

Journal of Clinical Investigation

V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity

Taka‐aki Koshimizu, Yoshihisa Nasa, Akito Tanoue, +10

Proceedings of the National Academy of Sciences

HypertensionHeart FailureNitric OxideNormal Blood PressureCardiovascular Function +14

Effects of the V2-Receptor Antagonist OPC-41061 and the Loop Diuretic Furosemide Alone and in Combination in Rats

Takahiro Hirano, Yoshitaka Yamamura, Shigeki Nakamura, +2

Journal of Pharmacology and Experimental Therapeutics

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist

Kazumi Kondo, Hidenori Ogawa, Hiroshi Yamashita, +9

Bioorganic & Medicinal Chemistry

Adenovirus-Mediated Gene Transfer of Glial Cell Line-Derived Neurotrophic Factor Prevents Ischemic Brain Injury after Transient Middle Cerebral Artery Occlusion in Rats

Hisashi Kitagawa, Chihoko Sasaki, Kenichi Sakai, +6

Journal of Cerebral Blood Flow & Metabolism

GliomaCerebral Vascular RegulationNeuroinflammationGdnf GeneBrain Injury +16