Nuclear envelope rupture and repair during cancer cell migration

Céline Denais, Rachel M. Gilbert, Philipp Isermann, +7

Science

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

Ashley Earle, Tyler J. Kirby, Gregory Fedorchak, +7

Nature Materials

Skeletal Muscle CellsGenome InstabilityMutant LaminsSkeletal MuscleMedicine +6

Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling

Monika Zwerger, Diana E. Jaalouk, Maria L. Lombardi, +6

Human Molecular Genetics

Nuclear StructureGeneticsNucleo-cytoskeletal CouplingMolecular BiologyCytoskeleton +19

Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments

Patricia M. Davidson, Josiah Sliz, Philipp Isermann, +2

Integrative Biology

High ResolutionEngineeringBiological MicroenvironmentsCytoskeletonOrgan-on-a-chip +21

A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration

Xuan Cao, Emad Moeendarbary, Philipp Isermann, +7

Biophysical Journal

MechanobiologyEngineeringNuclear MorphologyBiomechanicsCell-matrix Interaction +10

Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer

Emily Bell, Pragya Shah, Noam Zuela-Sopilniak, +13

Oncogene

Breast OncologyMetastatic CapacityMedicineCell-matrix InteractionCell Migration +7

High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells

Patricia M. Davidson, Gregory R. Fedorchak, Solenne Mondésert-Deveraux, +5

Lab on a Chip

Cellular and molecular remodelling of a host cell for vertical transmission of bacterial symbionts

Jun‐Bo Luan, Hong‐Wei Shan, Philipp Isermann, +4

Proceedings of the Royal Society B Biological Sciences

Cell migration through three-dimensional confining pores: speed accelerations by deformation and recoil of the nucleus

Marina Krause, Feng Wei Yang, Mariska te Lindert, +9

Philosophical Transactions of the Royal Society B Biological Sciences

Assays to Measure Nuclear Mechanics in Interphase Cells

Philipp Isermann, Patricia M. Davidson, Josiah Sliz, +1

Current Protocols in Cell Biology