Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Kazuko Haga, Andrew C. Kruse, Hidetsugu Asada, +8

Nature

Molecular PharmacologyG Protein-coupled ReceptorMedicineFunctional SelectivityPhysiology +5

Structure and function of an irreversible agonist-β2 adrenoceptor complex

Daniel M. Rosenbaum, Cheng Zhang, Joseph A. Lyons, +15

Nature

Molecular PharmacologyMolecular PhysiologySignal TransductionBiochemistryG Protein-coupled Receptor +5

High-resolution crystal structure of human protease-activated receptor 1

Cheng Zhang, Yoga Srinivasan, Daniel H. Arlow, +10

Nature

High-resolution Crystal StructureReceptor (Biochemistry)Molecular BiologyProtein X-ray CrystallographyStructural Biology

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

Yufei Xiang, Sham Nambulli, Zhengyun Xiao, +6

Science

Structural insights into the human D1 and D2 dopamine receptor signaling complexes

Youwen Zhuang, Peiyu Xu, Chunyou Mao, +19

Cell

Molecular PharmacologyHuman D1Functional SelectivityNeurotransmitterReceptor (Biochemistry) +8

Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

Changrui Xing, Youwen Zhuang, Ting-Hai Xu, +14

Cell

Cannabis UseMolecular PharmacologyMolecular PhysiologySignal TransductionG Protein-coupled Receptor +7

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

Matthieu Masureel, Yaozhong Zou, Louis-Philippe Picard, +13

Nature Chemical Biology

Molecular PharmacologyDrug TargetG Protein-coupled Receptorβ2Ar Partial AgonistMedicine +7

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

Xiaofeng Qi, Heng Liu, Bonne M. Thompson, +3

Nature

Biophysical ModelingBiochemistryNatural SciencesExperimental BiophysicsBiophysical Aspect +6

Cholesterol increases kinetic, energetic, and mechanical stability of the human β₂-adrenergic receptor

Michael Zocher, Cheng Zhang, Søren G. F. Rasmussen, +2

Proceedings of the National Academy of Sciences

Orthosteric and allosteric action of the C5a receptor antagonists

Heng Liu, Hee Ryung Kim, R. N. V. Krishna Deepak, +5

Nature Structural & Molecular Biology

Molecular PharmacologyFunctional SelectivityMedicineMechanism Of ActionReceptor (Biochemistry) +3