Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia–associated epilepsy

Théo Ribierre, Charlotte Deleuze, Alexandre Bacq, +9

Journal of Clinical Investigation

Mtorc1 Repressor Depdc5Brain DevelopmentCorticobasal DegenerationGeneticsSynaptic Signaling +16

Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response

Alexandre Bacq, Laure Balasse, Bruno P. Guiard, +9

Molecular Psychiatry

PsychiatryNeurophysiologyMedicinePsychotropic MedicationNeurotransmitter +11

Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice

Christine Kohl, Xiaodong Wang, Jocelyn Grosse, +9

Psychoneuroendocrinology

PsychoneuroimmunologyStress HormoneBehavioral NeuroscienceNeurobiological FactorBiological Embedding +11

Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling

Thomas Couroussé, Alexandre Bacq, Catherine Belzung, +8

Molecular Psychiatry

Molecular NeuroscienceMolecular PhysiologyStress HormoneNeurophysiologyPhysiology +11

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

Théo Ribierre, Alexandre Bacq, Florian Donneger, +13

Nature Neuroscience

Blockade of the high‐affinity noradrenaline transporter (NET) by the selective 5‐HT reuptake inhibitor escitalopram: an<i>in vivo</i>microdialysis study in mice

Hai T. Nguyen, Bruno P. Guiard, Alexandre Bacq, +6

British Journal of Pharmacology

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

Alexandre Bacq, Simone Astori, Elias Gebara, +10

Molecular Psychiatry

Cardiac Investigations in Sudden Unexpected Death in <scp><i>DEPDC5</i></scp>‐Related Epilepsy

Alexandre Bacq, Delphine Roussel, Thomas Bonduelle, +11

Annals of Neurology

The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents

Aurélie Papilloud, Meltem Weger, Alexandre Bacq, +9

Psychoneuroendocrinology

Behavioral SciencesBehavioral NeuroscienceNeuroanatomySocial BehaviorCrucial Role +11

Targeted suppression of mTORC2 reduces seizures across models of epilepsy

James T. Okoh, Jacqunae Mays, Alexandre Bacq, +11

Nature Communications

Synaptic PlasticityMtor Complex 1Neurobiology Of DiseaseNeurophysiologyMedicine +11