NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

Yang‐Sung Sohn, Sagi Tamir, Luhua Song, +13

Proceedings of the National Academy of Sciences

MitophagyBreast OncologyCell DeathTumor BiologyOxidative Stress +19

Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein

John A. Zuris, Yael Harir, Andrea R. Conlan, +9

Proceedings of the National Academy of Sciences

Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters

Merav Darash‐Yahana, Yair Pozniak, Mingyang Lu, +11

Proceedings of the National Academy of Sciences

The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer

Fang Bai, Faruck Morcos, Yang‐Sung Sohn, +13

Proceedings of the National Academy of Sciences

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1

Sagi Tamir, Shahar Rotem‐Bamberger, Chen Katz, +12

Proceedings of the National Academy of Sciences

Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells

Sarah H. Holt, Merav Darash‐Yahana, Yang Sung Sohn, +13

Journal of Cell Science

MitophagyBreast OncologyIron MetabolismApoptosisCell Death +22

Interactions between mitoNEET and NAF-1 in cells

Ola Karmi, Sarah H. Holt, Luhua Song, +12

PLoS ONE

MitophagyMolecular BiologyCell DeathRedox BiologyCellular Physiology +16

Nutrient-Deprivation Autophagy Factor-1 (NAF-1): Biochemical Properties of a Novel Cellular Target for Anti-Diabetic Drugs

Sagi Tamir, John A. Zuris, Lily Agranat, +9

PLoS ONE

MitophagyCell DeathRedox BiologyOxidative StressCell Autophagy +21

A point mutation in the [2Fe–2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties

Sagi Tamir, Y. Eisenberg-Domovich, Andrea R. Conlan, +7

Acta Crystallographica Section D Biological Crystallography

Protein AssemblyMolecular BiologyNaf-1 ProteinNaf-1 ExpressionCancer Biology +16

Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of IGF2-P3 and IGF2-P4 regulatory sequences.

Doron Amit, Sagi Tamir, Tatiana Birman, +2

PubMed