Aurora B kinase activation requires survivin priming phosphorylation by PLK1

Youjun Chu, Phil Y. Yao, Wenwen Wang, +7

Journal of Molecular Cell Biology

Molecular BiologyCytoskeletonAurora BCell CycleCellular Physiology +15

PLK1 Phosphorylates Mitotic Centromere-associated Kinesin and Promotes Its Depolymerase Activity

Liangyu Zhang, Hengyi Shao, Yuejia Huang, +9

Journal of Biological Chemistry

Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation

Hengyi Shao, Yuejia Huang, Liangyu Zhang, +7

Scientific Reports

Mitotic Regulator SKAP Forms a Link between Kinetochore Core Complex KMN and Dynamic Spindle Microtubules

Xiwei Wang, Xiaoxuan Zhuang, Dan Cao, +11

Journal of Biological Chemistry

Spindle MicrotubulesChromatinChromosome DynamicsCell DivisionChromosome Segregation +11

Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders

Liang Xu, Andrea Carrer, Francesco Zonta, +25

Frontiers in Molecular Neuroscience

SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis

Lingluo Chu, Tongge Zhu, Xing Liu, +9

Journal of Molecular Cell Biology

Regulation of a Dynamic Interaction between Two Microtubule-binding Proteins, EB1 and TIP150, by the Mitotic p300/CBP-associated Factor (PCAF) Orchestrates Kinetochore Microtubule Plasticity and Chromosome Stability during Mitosis

Tarsha Ward, Ming Wang, Xing Liu, +13

Journal of Biological Chemistry

A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice

Yuanyuan Kuang, Veronica Zorzi, Damiano Buratto, +18

EBioMedicine

Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy

Tianping Peng, Xiujian Ma, Wei Hua, +46

Cell stem cell

Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics

Ruoying Yu, Huihui Wu, Hazrat Ismail, +21

Journal of Molecular Cell Biology

Biophysical ModelingMolecular RegulationGeneticsMolecular BiologyCytoskeleton +17